function:GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 1 START domain.,subunit:Homodimer. Interacts with TAX1BP1.,tissue specificity:Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.,
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.
Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.