disease:Defects in SURF1 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions that is commonly associated with systemic cytochrome c oxidase (COX) deficiency.,function:Probably involved in the biogenesis of the COX complex.,similarity:Belongs to the SURF1 family.,
Mitochondrion inner membrane ; Multi-pass membrane protein .
Colon,Kidney,Skin,Stomach,
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