TAP Polyclonal Antibody

domain:The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus.,domain:The minimal CTE binding domain consists of an RNP-type RNA binding domain (RBD) and leucine-rich repeats.,domain:The nucleoporin binding domain consists of a NTF2-like domain and a TAP domain (also called UBA-like domain). The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required for NXF1-mediated nuclear mRNA export. The TAP domain mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF1 to the nuclear rim. The conserved loop 594-NWD-596 of the UBA domain has a critical role in the interaction with nucleoporins.,function:Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm.,miscellaneous:The RNA-binding domain is a non-canonical RNP-type domain.,similarity:Belongs to the NXF family.,similarity:Contains 1 NTF2 domain.,similarity:Contains 1 RRM (RNA recognition motif) domain.,similarity:Contains 1 TAP-C domain.,similarity:Contains 4 LRR (leucine-rich) repeats.,subcellular location:Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm.,subunit:Interacts with NXT1, NXT2, E1B-AP5, RAE1, THOC4 and with several nucleoporins. Is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, RENT1, RENT2, RENT3A, RENT3B and THOC4. Found in a mRNA complex with RENT3A and RENT3B. Interacts with Saimiriine herpesvirus 2 TIP protein. Interacts with NUPL2.,tissue specificity:Expressed ubiquitously.,