domain:The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.,function:Acts as a calcium-activated chloride channel. Required for normal tracheal development.,similarity:Belongs to the anoctamin family.,tissue specificity:Broadly expressed with higher levels in liver and skeletal muscle.,
Cell membrane ; Multi-pass membrane protein . Cytoplasm . Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors. .
Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles.
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