catalytic activity:ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.,function:Possesses negatively supercoiled DNA relaxing activity.,similarity:Belongs to the prokaryotic type I/III topoisomerase family.,tissue specificity:Isoform 1 is found in testis, heart and skeletal muscle. A 4 kb transcript which probably represents isoform 2 is found in thymus, kidney and pancreas.,
condensed chromosome,nucleus,cytosol,
Isoform 1 is found in testis, heart and skeletal muscle. A 4 kb transcript which probably represents isoform 2 is found in thymus, kidney and pancreas.
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