catalytic activity:L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.,cofactor:Fe(2+) ion.,disease:Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].,pathway:Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.,similarity:Contains 1 ACT domain.,tissue specificity:Brain specific.,
cytosol,neuron projection,
Brain specific.
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