TTF-I Polyclonal Antibody

domain:The N-terminal region inhibits DNA-binding via its interaction with the C-terminal region.,function:Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with TIP5 recovers DNA-binding activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,sequence caution:Contaminating sequence. Sequence of unknown origin in the C-terminal part.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Contains 2 Myb-like domains.,subunit:Oligomer. The oligomeric structure enables to interact simultaneously with two separate DNA fragments. Interacts with TIP5.,