caution:Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family.,function:E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the RBR family. RNF144 subfamily.,similarity:Contains 1 IBR-type zinc finger.,similarity:Contains 2 RING-type zinc fingers.,subunit:Interacts with UBE2L3.,
Cell membrane ; Single-pass membrane protein . Cytoplasmic vesicle membrane .
Bone marrow,Ovary,
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