UCP2 Polyclonal Antibody

function:UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.,polymorphism:Genetic variation in UCP2 influences susceptibility to obesity [MIM:607447]; also called body mass index quantitative trait locus type 4 (BMIQ4). Obesity is the most common nutritional disorder in Western society.,similarity:Belongs to the mitochondrial carrier family.,similarity:Contains 3 Solcar repeats.,subunit:Acts as a dimer forming a proton channel.,tissue specificity:Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.,