function:Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.,induction:Up-regulated by IL-1-alpha and TNF-alpha.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,tissue specificity:Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.,
Membrane ; Single-pass type II membrane protein .; [Tumor necrosis factor ligand superfamily member 15, secreted form]: Secreted.
Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.
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