domain:Composed of an N-terminal domain, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.,function:May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PID domain.,similarity:Contains 2 PDZ (DHR) domains.,subunit:Binds to the cytoplasmic domain of amyloid protein (APP) in vivo.,tissue specificity:Expressed in all the tissues examined with lower levels in brain and testis.,
Cytoplasm, perinuclear region .
Expressed in all tissues examined with lower levels in brain and testis.
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