disease:A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with MLL/HRX.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 FYVE-type zinc finger.,tissue specificity:Detected in brain, heart, skeletal muscle, kidney and liver.,
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cleavage furrow . Midbody, Midbody ring . Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis. .
Detected in brain, heart, skeletal muscle, kidney and liver.
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