translation, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process,apoptosis, virus-infected cell apoptosis, ER-nuclear signaling pathway, response to unfolded protein, cell death,negative regulation of cell proliferation, response to virus, response to organic substance, programmed cell death,death, phosphorylation, endoplasmic reticulum unfolded protein response, cellular response to stress, regulation of osteoblast proliferation, negative regulation of osteoblast proliferation, cellular response to unfolded protein,response to endoplasmic reticulum stress, regulation of cell proliferation, protein amino acid autophosphorylation,response to protein stimulus,
Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Nuclear localization is elevated in acute leukemia, myelodysplastic syndrome (MDS), melanoma, breast, colon, prostate and lung cancer patient samples or cell lines as well as neurocytes from advanced Creutzfeldt-Jakob disease patients. .
Highly expressed in thymus, spleen and bone marrow compared to non-hematopoietic tissues such as small intestine, liver, or kidney tissues. Colocalizes with GSK3B and TAU in the Alzheimer disease (AD) brain. Elevated levels seen in breast and colon carcinomas, and which correlates with tumor progression and invasiveness or risk of progression.
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