function:Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.,miscellaneous:Does not bind interleukin 1 alpha (IL-1A) or interleukin 1 beta (IL-1B).,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression in Hodgkin's disease cell lines.,
Membrane ; Single-pass type I membrane protein .
Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells (PubMed:10925275, PubMed:11046021, PubMed:10653850).
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