caution:It is uncertain whether Met-1 or Met-3 is the initiator.,developmental stage:Low level expression in the developing fetus, increased in the neonate, and maximal in the adult.,disease:Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.,function:May function as a tRNA-specific ribonuclease that binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus, thereby promoting the endothelial invasiveness necessary for blood vessel formation. Angiogenin induces vascularization of normal and malignant tissues. Abolishes protein synthesis by specifically hydrolyzing cellular tRNAs.,online information:Angiogenin,similarity:Belongs to the pancreatic ribonuclease family.,tissue specificity:Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.,
Cytoplasmic vesicle, secretory vesicle lumen . Secreted . Nucleus . Nucleus, nucleolus . Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (PubMed:12051708). .
Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
下载说明书
