catalytic activity:Cleaves the N-propeptide of collagen chain alpha-1(I) at Pro-|-Gln and of alpha-1(II) and alpha-2(I) at Ala-|-Gln.,caution:Has sometimes been referred to as ADAMTS3.,cofactor:Binds 1 zinc ion per subunit.,disease:Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C) [MIM:225410]. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7C is marked by extremely fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis laxa syndrome.,domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,function:Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 4 TSP type-1 domains.,subunit:May belong to a multimeric complex. Binds specifically to collagen type XIV.,tissue specificity:Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.,
Secreted, extracellular space, extracellular matrix .
Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.
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