microtubule cytoskeleton organization, mitotic cell cycle, M phase, cytoskeleton organization, microtubule-based process, microtubule depolymerization, cell cycle, spindle organization, mitotic spindle organization, intracellular signaling cascade, cell cycle process, cell cycle phase, cellular component disassembly, microtubule polymerization or depolymerization, macromolecular complex disassembly, cellular macromolecular complex subunit organization, cellular macromolecular complex disassembly, protein complex disassembly, cellular protein complex disassembly,macromolecular complex subunit organization, protein depolymerization,
Cytoplasm, cytoskeleton.
Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
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