ASPP1 Polyclonal Antibody

disease:Defects in PPP1R13B may be a cause of breast cancers. It is overexpressed in many patients suffering from breast carcinomas and expressing a wild-type TP53 protein.,domain:The ankyrin repeats and the SH3 domain are required for specific interactions with TP53.,function:Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.,miscellaneous:In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1. This name was given due to its similarity with a protein that binds to protein phosphatase 1.,similarity:Belongs to the ASPP family.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 ANK repeats.,subcellular location:Predominantly cytoplasmic. Some fraction is nuclear.,subunit:Interacts with TP53.,