disease:Defects in POMC are the cause of pro-opiomelanocortinin deficiency [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair.,disease:Defects in POMC may be associated with susceptibility to obesity [MIM:601665].,function:ACTH stimulates the adrenal glands to release cortisol.,function:Beta-endorphin and Met-enkephalin are endogenous opiates.,function:MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.,online information:Melanocyte-stimulating hormone entry,PTM:O-glycosylated; reducing sugar is probably N-acetylgalactosamine.,PTM:Specific enzymatic cleavages at paired basic residues yield the different active peptides.,similarity:Belongs to the POMC family.,tissue specificity:ACTH and MSH are produced by the pituitary gland.,
Secreted . Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms. .
ACTH and MSH are produced by the pituitary gland.
下载说明书
