function:Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).,similarity:Belongs to the cyclin family. Cyclin C subfamily.,subunit:Associates with CDK9 to form P-TEFb. Isoform A and isoform B interact with HIV-2 and SIV Tat. Does not bind efficiently to the transactivation domain of the HIV-1 Tat.,tissue specificity:Ubiquitously expressed.,
Cytoplasm, perinuclear region . Nucleus . Nucleus in differentiating cells. .
Ubiquitously expressed.
下载说明书
