catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,function:Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subcellular location:In peripheral neurons, expressed both at the plasma membrane and in nuclei.,subunit:Interacts with RAD18 and UBR2.,
Cell membrane . Nucleus . In peripheral neurons, expressed both at the plasma membrane and in nuclei. .
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