PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 3 LRR (leucine-rich) repeats.,similarity:Contains 5 WD repeats.,
Nucleus . Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3.
Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS).
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