function:Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels.,miscellaneous:Marker of a cell type preferentially transformed by neu or ras oncoprotein.,similarity:Belongs to the FXYD family.,tissue specificity:Expressed in a subset of human breast tumors.,
Cell membrane ; Single-pass type I membrane protein .
Isoform 1: Expressed mainly in differentiated cells (at protein level). Isoform 2: Expressed mainly in undifferentiated cells (at protein level).
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