similarity:Contains 6 LRR (leucine-rich) repeats.,subcellular location:Although predicted to be a single-pass type I membrane protein, this protein localizes to the cytoplasm when expressed at high levels (PubMed:15164053).,tissue specificity:Expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer.,
Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Localizes to the cytoplasm when expressed at high levels. .
Isoform 1 is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Isoform 1 is expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer. Isoform 2 is expressed in cancer cell lines.
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