disease:Quantitative or qualitative alterations of expression have not been detected in facioscapulohumeral muscular dystrophy (FSHD).,function:May play a role in the organization of actin filament arrays within muscle cells.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Localizes to myofiber Z-lines.,subunit:Interacts with ACTN2.,tissue specificity:Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.,
Cytoplasm, myofibril, sarcomere, Z line . Localizes to myofiber Z-lines.
Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.
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