similarity:Contains 1 RING-type zinc finger.,tissue specificity:Predominantly expressed in brain.,
Membrane ; Multi-pass membrane protein . Membrane ; Peripheral membrane protein . Cytoplasm . Nucleus . Nucleus, nuclear body . Nucleus, nucleoplasm . Endosome . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . Cell junction, synapse, postsynaptic density . Perikaryon . Cell projection, neuron projection . Predominantly in the nucleus, but some amounts were also found in the cytoplasm. Oxidative stress stimulates its shuttling from the cytoplasm into the nucleus. Recruited to nuclear bodies via its interaction with ZBTB16. Localizes to the cell soma and neuritis and only slightly to the nucleus in the neurons of most brain areas. .
Predominantly expressed in brain (PubMed:10574464). Decreased expression in glioma brain tumors as compared to normal brains (at protein level) (PubMed:28684796).
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