function:Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.,PTM:Phosphorylated.,similarity:Contains 1 DAPIN domain.,subunit:Interacts with PYCARD/ASC.,tissue specificity:Predominantly expressed in monocytes, macrophages and granulocytes.,
Cytoplasm . Recruited to specks formed by PYCARD within the cytoplasm. .
Predominantly expressed in monocytes, macrophages and granulocytes.
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