catalytic activity:Leukotriene C(4) = leukotriene A(4) + glutathione.,disease:Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.,function:Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.,similarity:Belongs to the MAPEG family.,subunit:Homotrimer. Interacts with ALOX5AP and ALOX5.,tissue specificity:Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets.,
Nucleus outer membrane ; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein. Nucleus membrane ; Multi-pass membrane protein.
Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets.
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