function:Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.,similarity:Belongs to the VPS37 family.,similarity:Contains 1 VPS37 C-terminal domain.,subcellular location:Probably associates with membranes. Recruited to the plasma membrane by HIV-1.,subunit:Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and a FAM125/MVB12 protein (FAM125A or -B) in a 1:1:1:1 stoechiometry. Interacts with TSG101, VPS28, FAM125A and FAM125B. Interacts with HGS and STAM2. Interacts with CEP55.,
Late endosome membrane ; Peripheral membrane protein . Probably associates with membranes. Recruited to the plasma membrane by HIV-1.
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