catalytic activity:N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline.,cofactor:Binds 1 zinc ion.,function:Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in nitric oxide generation.,similarity:Belongs to the DDAH family.,subunit:Monomer.,
mitochondrion,cytosol,extracellular exosome,
Detected in brain, liver, kidney and pancreas, and at low levels in skeletal muscle.
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