function:Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemi-methylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Isoform 1 may enhance the activation of some unmethylated cAMP-responsive promoters. Reports about DNA demethylase activity of isoform 2 are contradictory.,similarity:Contains 1 MBD (methyl-CpG-binding) domain.,subcellular location:Nuclear, in discrete foci. Detected at replication foci in late S phase.,subunit:Heterodimer with MBD3. Part of the MeCP1 complex that contains HDAC1 and HDAC2. Binds DNMT1, MIZF, XAB1, SIN3A, p66-alpha and p66-beta. Isoform 1 binds DHX9, but isoform 2 does not.,tissue specificity:Highly expressed in brain, heart, kidney, stomach, testis and placenta.,
Nucleus . Nuclear, in discrete foci. Detected at replication foci in late S phase.
Highly expressed in brain, heart, kidney, stomach, testis and placenta.
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