catalytic activity:tRNA uridine = tRNA pseudouridine.,function:Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Partially unspliced pre-RNA.,similarity:Belongs to the pseudouridine synthase Pus10 family.,
Nucleus . Cytoplasm . Mitochondrion . Localizes mainly in the nucleus (Probable) (PubMed:31819270). tRNA pseudouridylate synthase activity is restricted to the cytoplasm (PubMed:31819270). Translocates from nucleus to mitochondria during TRAIL-induced apoptosis (PubMed:28981101). .
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