domain:The OTU domain mediates the deubiquitinating activity.,domain:The RanBP2-type zinc fingers mediate the specific interaction with 'Lys-63'-linked ubiquitin.,function:Positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. Acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription. May also modulate TNF-alpha signaling.,similarity:Belongs to the peptidase C64 family.,similarity:Contains 1 OTU domain.,similarity:Contains 3 RanBP2-type zinc fingers.,subunit:Interacts with APC and TRAF6.,tissue specificity:Widely expressed.,
Cytoplasm . Nucleus . Enriched in punctate localization in the cytoplasm. .
Widely expressed.
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