Endoplasmic reticulum membrane ; Single-pass type III membrane protein . Cytoplasmic vesicle, autophagosome . Cytoplasm, cytosol . Nucleus . Chromosome . Is trafficked from tubular ER to growing autophagosomes via its cytosolic LIR motif (PubMed:31006537). Also found in the cytosol, nucleus and chromatin (PubMed:32152270). In response to formation of covalent DNA-protein cross-links (DPCs), localizes to the nuclear periphery, and associates with DNA replication forks (PubMed:32152270). .
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