domain:Amphipathic helix regions act as an anchoring domain for PKA, and appear to be responsible of the interaction between myospryn and PRKAR2A.,induction:Down-regulated in muscle cell lines derived from patients with Duchenne muscular dystrophy (DMD).,sequence caution:Contaminating sequence. Potential poly-A sequence.,sequence caution:Translated as Trp.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 2 fibronectin type-III domains.,subcellular location:Found predominantly at the periphery of the nucleus but also throughout the cell. Localized at the Z-line costamere connection level of the sarcolemma and in lysosomes.,subunit:Interacts with ACTN2, DTNBP1/dysbindin and PRKAR2A (By similarity). Interacts with DES.,tissue specificity:Expressed in skeletal muscle; at a strong level and in heart.,
Nucleus . Sarcoplasmic reticulum . Cytoplasm . Cytoplasm, perinuclear region . Cytoplasm, myofibril, sarcomere, M line . Found predominantly at the periphery of the nucleus but also throughout the cell. Localized in lysosomes (By similarity). In skeletal muscles, localizes along myofiber periphery, at costameres (By similarity). Predominantly flanks Z-disks (By similarity). Occasionally present at the M-band level. Colocalized with RYR2 in the sarcoplasmic reticulum (By similarity). .
Expressed in skeletal muscle; at a strong level and in heart.
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