caution:Despite its name, it does not share sequence similarity with the poliovirus receptor (PVR/CD155) and does not contain any immunoglobulin domain.,
Cell membrane ; Multi-pass membrane protein .
Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-cell expression levels are variable among individuals. Not detected in B-cells, naive or helper T-cells, monocytes, nor neutrophils (at protein level). Not detected in dendritic cells.
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