catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.,function:Hydrolyzes the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.,similarity:Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family.,similarity:Contains 1 Rho-GAP domain.,tissue specificity:Platelets.,
Cytoplasm, cytosol . Endoplasmic reticulum-Golgi intermediate compartment . Early endosome membrane . Membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle, phagosome membrane . Golgi apparatus .
Platelets.
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