function:May play a role in the maturation and maintenance of blood-brain barrier.,similarity:Contains 2 Ig-like V-type (immunoglobulin-like) domains.,
Cell membrane ; Single-pass type I membrane protein . Cell junction, tight junction . Cytoplasm . Cell projection, cilium membrane . Nucleus . Primarily localizes to the cell membrane (PubMed:23386276). Detected in the cilium of primary chondrocytes (By similarity). Highly expressed at areas of cell-cell contact and may localize to tight junctions (By similarity). Also found in the nucleus where it is detected in the soluble (as opposed to chromatin-bound) fraction (PubMed:23386276). .
Detected in endothelial cells in mammary tissue, in both large vessels (left internal mammary artery) and small capillaries (vasa vasorum of the adventitia).
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