catalytic activity:L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3).,cofactor:Binds 1 zinc ion per subunit.,function:Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.,similarity:Belongs to the glutaminyl-peptide cyclotransferase family.,
Secreted .
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