CPSF5 rabbit pAb

function:Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.,miscellaneous:Has no hydrolase activity as missing metal-binding sites in NUDIX motif.,PTM:Acetylated mainly by p300/CBP, recruited to the complex by CPSF6. Acetylation decreases interaction with PAPAO. Deacetylated by the class I/II HDACs, HDAC1, HDAC3 and HDAC10, and by the class III HDACs, SIRT1 AND SIRT2.,similarity:Belongs to the Nudix hydrolase family. CPSF5 subfamily.,similarity:Contains 1 nudix hydrolase domain.,subcellular location:In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.,subunit:Homodimer. Component of the cleavage factor Im (CFIm) complex, composed of, at least, NUDT21/CPSF5 and CPSF6 or CPSF7. Interacts with CPSF6, PABPN1 and SNRNP70. Interacts with PAPOLA; the interaction is diminished by acteylation.,