catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear.,similarity:Belongs to the peptidase M67A family. PSMD14 subfamily.,similarity:Contains 1 MPN (JAB/Mov34) domain.,subunit:Component of the 19S regulatory cap of the 26S proteasome.,tissue specificity:Widely expressed. Highest levels in heart and skeletal muscle.,
proteasome complex,nucleus,nucleoplasm,cytosol,proteasome regulatory particle, lid subcomplex,proteasome accessory complex,cytosolic proteasome complex,extracellular exosome,
Widely expressed. Highest levels in heart and skeletal muscle.
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