disease:Autoantigen found in patients with the watermelon stomach disease, which is characterized by prominent stripes of ectatic vascular tissue in the stomach similar to stripes on a watermelon. Chronic gastrointestinal bleeding occurs and approximately half of the patients have associated autoimmune disorders.,domain:The 3 X 5 AA repeats seem to be critical for the RNA folding activity.,domain:The two enzymatic activities reside in two separate domains, the helicase in the N-terminus and the foldase in the C-terminus.,function:Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription. Involved in rRNA processing.,similarity:Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subunit:Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21.,
Nucleus, nucleolus . Nucleus, nucleoplasm . Cytoplasm, cytosol . Mitochondrion . Present both in nucleolus and nucleoplasm. Interaction with JUN promotes translocation from the nucleolus to the nucleoplasm (PubMed:11823437, PubMed:18180292). Interaction with WDR46 is required for localization to the nucleolus (PubMed:23848194). Colocalizes in the cytosol with DDX1, DHX36 and TICAM1. The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) RNA ligand stimulation (By similarity). .
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