similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 1 SRCR domain.,subcellular location:Activated by cleavage and secreted.,tissue specificity:Expressed strongly in small intestine. Also expressed in prostate, colon, stomach and salivary gland.,
Cell membrane ; Single-pass type II membrane protein .; [Transmembrane protease serine 2 catalytic chain]: Secreted . Activated by cleavage and secreted. .
Expressed in several tissues that comprise large populations of epithelial cells with the highest level of transcripts measured in the prostate gland. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon, stomach and salivary gland. Coexpressed with ACE2 within lung type II pneumocytes, ileal absorptive enterocytes, intestinal epithelial cells, cornea, gallbladder and nasal goblet secretory cells (Ref.21).
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