function:Plays a fundamental role in microtubule-organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CEP110.,miscellaneous:Binds two moles of calcium per mole of protein.,similarity:Belongs to the centrin family.,similarity:Contains 4 EF-hand domains.,subcellular location:Centrosome of S-phase, interphase and mitotic cells.,subunit:Monomer. Interacts with CEP110, SFI1 and with XPC.,
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Nucleus envelope . Nucleus, nuclear pore complex . Nucleus .
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