domain:Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.,function:Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.,similarity:Belongs to the metallothionein superfamily. Type 1 family.,subunit:Monomer.,
nucleus,cytoplasm,perinuclear region of cytoplasm,
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