disease:Defects in RP1 are the cause of retinitis pigmentosa type 1 (RP1) [MIM:180100]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.,function:Could have a role in the differentiation of photoreceptor cells.,online information:Retina International's Scientific Newsletter,online information:Retinal information network,similarity:Contains 2 doublecortin domains.,tissue specificity:Expressed in retina. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, spleen and pancreas.,
Cytoplasm, cytoskeleton, cilium axoneme . Cell projection, cilium, photoreceptor outer segment . Specifically localized in the connecting cilia of rod and cone photoreceptors.
Expressed in retina. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, spleen and pancreas.
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