developmental stage:Initially observed in the Bowman capsule during early glomerular capillary loop formation in the kidney. In more developmentally mature glomeruli, following transition from early to mid-capillary loop stage, expression is higher in the proximal tubular basement membrane than in the distal basement membrane and Bowman capsule.,disease:Antibodies against TINAG are found in sera of patients with tubulointerstitial nephritis, a rare autoimmune disorder that causes acute and chronic renal injury.,function:Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3.,PTM:It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus 2 alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.,similarity:Belongs to the peptidase C1 family.,similarity:Contains 1 SMB (somatomedin-B) domain.,tissue specificity:Expressed in the kidney cortex, small intestine and cornea.,
Secreted, extracellular space, extracellular matrix, basement membrane .
Expressed in the kidney cortex, small intestine and cornea.
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