disease:A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma. Translocation t(1;10)(p22;q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural transcript which is normally not translated.,function:Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.,induction:Down-regulated during mitosis through proteasomal degradation.,miscellaneous:Depletion of EVI5 by RNAi causes cell cycle arrest and mitotic abnormalities.,PTM:Probably phosphorylated by PLK1; may be required for degradation during mitosis.,PTM:Ubiquitinated. Degradation during prophase is ubiquitin-dependent.,similarity:Contains 1 Rab-GAP TBC domain.,subcellular location:Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.,subunit:Dimeric and monomeric. Interacts with alpha- and gamma-tubulin. Interacts with FBXO5. Interacts with the chromosome passenger complex (CPC) which is at least composed of AURKB/aurora-B, BIRC5/survivin, CDCA8/borealin and INCENP.,tissue specificity:Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal.,
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.
Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal.
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