function:Transport of small lipophilic substances .,similarity:Belongs to the calycin superfamily. Lipocalin family.,subunit:Forms a covalently linked, disulfide-bridged heterodimer with the 92 kDa type V collagenase (MMP-9).,tissue specificity:Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lungs. Not found in the small intestine or peripheral blood leukocytes.,
Secreted . Cytoplasmic granule lumen . Cytoplasmic vesicle lumen . Upon binding to the SLC22A17 (24p3R) receptor, it is internalized (By similarity). Releases the bound iron in the acidic lumen of cytoplasmic vesicles (PubMed:12453413, PubMed:20581821). .
Detected in neutrophils (at protein level) (PubMed:7683678, PubMed:8298140). Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes.
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