function:Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.,PTM:O-glycosylation; glycosaminoglycan of chondroitin-sulfate type.,similarity:Belongs to the apolipoprotein O family.,tissue specificity:Expressed in all tissues examined. Up-regulated in diabetic heart.,
Mitochondrion inner membrane ; Single-pass membrane protein . Secreted . Mitochondrion . Golgi apparatus membrane . Endoplasmic reticulum membrane . Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form. .
Expressed in all tissues examined. Up-regulated in diabetic heart.
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